NKT and T cells: coordinate regulation of NK-like phenotype and cytokine production.
摘要：
A maturation-dependent change in phenotype and cytokine production from relatively immature CD161– or CD161+, IL-13+IL-4+, IFN-γ–, to mature CD161+CD56+ IFN-γ+ cells occurs in primary human α-galactosyl ceramide-reactive CD1d-restricted natural killer T (NKT) cells under the control of IL-12 and other monokines. Modulation of this process upon α-galactosyl ceramide stimulation explains the opposite roles of NKT cells to drive type 1 and type 2 immune responses. Because the samedevelopmental changes occurred and were similarly regulated in T cells, the data establish that NKT cells should no longer be considered a functionally unique regulatory subset. However, the results of their analysis can be taken as a model for immunotherapeutic approaches with T cells for which a nominal or surrogate antigen is defined.
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DOI：
10.1002/1521-4141(200212)32:12<3453::AID-IMMU3453>3.0.CO;2-D
被引量：
年份：
2015
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