p53 exon 7 mutations as a predictor of poor prognosis in patients with colorectal cancer.
摘要：
We have studied 61 resected colorectal adenocarcinomas in order to investigate mutations as a prognostic factor for this pathology. Mutations in exons 5–9 of the gene were analyzed by the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) technique followed by sequencing. Our data indicate that exon 7 mutations were prevalent in the latest stages of colorectal carcinogenesis and patients bearing this alteration had the worst prognosis. Therefore, according to our results, mutations affecting exon 7 of the gene could be considered as a useful marker of biological aggressiveness for colorectal cancer.
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DOI：
info:doi/10.1016/S0304-3835(98)00138-4
被引量：
年份：
1998
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