Antielastin autoimmunity in tobacco smoking–induced emphysema
摘要：
Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.
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关键词：
Humans B-Lymphocytes T-Lymphocytes Lung Pulmonary Disease, Chronic Obstructive Emphysema Smoking Autoimmunity T-Lymphocytes, Regulatory Elastin
DOI：
10.1038/nm1583
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万方医学
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