摘要：

Objective:To discuss the effect of intensity modulated radiation therapy combined with paclitaxel+ endostar chemotherapy on serum malignant molecule levels in patients with locally advanced non-small cell lung cancer.Methods:Patients with locally advanced NSCLC who were treated in the hospital between February 2015 and January 2017 were collected and divided into control group(n=59)and research group(n=59)by random number table.Control group received the routine paclitaxel+endostar chemotherapy after the operation,and research group underwent intensity modulated radiation therapy combined with paclitaxel+ endostar chemotherapy after the operation.The differences in serum levels of NSCLC-related tumor markers and angiogenesis indexes were compared between the two groups before and after treatment.Results:Before treatment,the differences in serum levels of NSCLC-related tumor markers and angiogenesis indexes were not statistically significant between the two groups.After treatment,serum TK1,CYFRA21-1,Pro-GRP,CEA,CA125 and SCC-Ag levels of research group were lower than those of control group;serum EGFR,COX-2,VEGF,HIF-1α and MMP-2 levels of research group were lower than those of control group.Conclusion:Postoperative intensity modulated radiation therapy combined with paclitaxel+ endostar chemotherapy can effectively reduce the serum malignant molecule levels and optimize the illness in patients with local advanced NSCLC.

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