Targeting polo-like kinase 1 for cancer therapy
摘要：
Human polo-like kinase 1 (PLK1) is essential during mitosis and in the maintenance of genomic stability. PLK1 is overexpressed in human tumours and has prognostic potential in cancer, indicating its involvement in carcinogenesis and its potential as a therapeutic target. The use of different PLK1 inhibitors has increased our knowledge of mitotic regulation and allowed us to assess their ability to suppress tumour growth in vivo. We address the structural features of the kinase domain and the unique polo-box domain of PLK1 that are most suited for drug development and discuss our current understanding of the therapeutic potential of PLK1.
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关键词：
Cell Cycle Proteins Gene Silencing Neoplasms Protein-Serine-Threonine Kinases 细胞周期蛋白质类 肿瘤 蛋白质丝氨酸苏氨酸激酶 原癌基因蛋白质类
DOI：
10.1038/nrc1841
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Nature
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