Aurora B Phosphorylates Centromeric MCAK and Regulates Its Localization and Microtubule Depolymerization Activity
摘要：
itotic entromere-ssociated inesin) is a Kin I kinesin that can depolymerize microtubules. These two proteins both localize to mitotic centromeres and have overlapping mitotic functions, including regulation of microtubule dynamics, proper chromosome congression, and correction of improper kinetochore-microtubule attachments.Conclusions: We have established a direct link between the microtubule depolymerase MCAK and Aurora B kinase. Our data suggest that Aurora B both positively and negatively regulates MCAK during mitosis. We propose that Aurora B biorients chromosomes by directing MCAK to depolymerize incorrectly oriented kinetochore microtubules.
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关键词：
Animals Xenopus Microtubules Kinetochores Kinesin Cell Extracts Biotinylation Fluorescent Antibody Technique Precipitin Tests Phosphorylation
DOI：
10.1016/j.cub.2004.01.055
被引量：
年份：
2004
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