Proliferation in human bladder carcinoma measured by Ki-67 antibody labelling: its potential clinical importance.
摘要：
Ki-67 is a monoclonal which recognises a expressed in proliferating . The was used to assess proliferation in primary bladder from 64 patients. Ki-67 index (the number of Ki-67 positive divided by the total number of %) was derived from 59 tumours. A wide range of Ki-67 indices were recorded, range 3.0-65.8%, mean 20.2%. The Ki-67 index correlated with known prognostic factors: T stage (P = 0.002) and histological grade (P less than 0.001), early stage disease and more differentiated having lower Ki-67 indices. Patients with invasive disease (21 patients) had significantly higher Ki-67 indices than those with non-invasive disease (P = 0.01). Patients with at presentation (four cases) all had a Ki-67 index of greater than or equal to 29%. Ki-67 staining is a simple technique for assessing the proliferation fraction than can be performed on a small amount of tissue taken at routine biopsy without prior injection of analogues.
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关键词：
Humans Nuclear Proteins Ki-67 Antigen Antibodies, Monoclonal Biopsy Cell Division Aged Middle Aged Female Male
DOI：
10.1080/09553008914552131
被引量：
年份：
1991
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