Lesional expression of interferon-gamma in atopic eczema.
摘要：
Atopic eczema is thought to be caused by skin-infiltrating CD4 T cells of the Th 1 -like and/or Th 2 -like subtype. We assessed expression of the Th 1 -like cytokine, interferon-γ, and the Th 2 -like cytokine, interleukin-4, in lesional atopic skin. Compared with that in normal skin, interferon-γ and interleukin-4 mRNA expression were increased in eczematous skin lesions in 13 and 4 of 15 patients, respectively. After successful therapy of atopic dermatitis, the increased interferon-γ mRNA expression but not the increased interleukin-4 mRNA expression was significantly downregulated. These data indicate that in-situ expression of interferon-γ is linked to the clinical course of atopic dermatitis.
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关键词：
Humans Dermatitis, Atopic Cell Adhesion Molecules Intercellular Adhesion Molecule-1 Interleukin-2 Interleukin-4 Interferon-gamma RNA, Messenger
DOI：
10.1016/S0140-6736(94)90879-6
被引量：
年份：
1994
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