Stem Cells and the Niche: A Dynamic Duo
摘要：
Stem cell niches are dynamic microenvironments that balance stem cell activity to maintain tissue homeostasis and repair throughout the lifetime of an organism. The development of strategies to monitor and perturb niche components has provided insight into the responsive nature of the niche and offers a framework to uncover how disruption of normal stem cell niche function may contribute to aging and disease onset and progression. Additional work in the identification of genetic factors that regulate the formation, activity, and size of stem cell niches will facilitate incorporation of the niche into stem cell-based therapies and regenerative medicine.
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关键词：
Animals Humans Stem Cell Transplantation Cell Lineage Cell Differentiation Stem Cell Niche Regeneration Stem Cells
DOI：
10.1016/j.stem.2010.01.011
被引量：
年份：
2010
Elsevier
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Elsevier
万方医学
掌桥科研
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Elsevier
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Europe PMC
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Cell Press
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NCBI
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core.ac.uk
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