What's Up and Down with Histone Deacetylation and Transcription?

Cell. 1997 May 2;89(3):325-8. Review

MJ Pazin，JT Kadonaga - 《Cell》

Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway.

Survivin is an inhibitor of apoptosis protein, which is over-expressed in most tumors. Aberrant expression of survivin and loss of wild-type p53 in many tu...

A Mirza，M Mcguirk，TN Hockenberry，... - 《Oncogene》

Suppression of Vascular Endothelial Growth Factor-Mediated Endothelial Cell Protection by Survivin Targeting

The protective genes that mediate endothelial cell (EC) survival during angiogenesis have not been completely characterized. Here, we show that an antisens...

M Mesri，M Moralesruiz，EJ Ackermann，... - 《American Journal of Pathology》

Survivin-ΔEx3 and Survivin-2B: Two Novel Splice Variants of the Apoptosis Inhibitor Survivin with Different Antiapoptotic Properties

Recently, a novel antiapoptosis gene, i.e., survivin, was identified as a structurally unique member of the inhibitor of apoptosis protein family. Survivin...

C Mahotka，M Wenzel，E Springer，... - 《Cancer Research》

Survivin apoptosis: an interloper between cell death and cell proliferation in cancer.

Lab Invest. 1999 Nov;79(11):1327-33. Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review

DC Altieri，PC Marchisio - 《Laboratory Investigation》

The molecular basis and potential role of survivin in cancer diagnosis and therapy.

Survivin has regulatory function in cell proliferation and cell death, two processes that are central to cancer, which offers new opportunities for cancer ...

DC Altieri - 《Trends in Molecular Medicine》

Inhibition of melanoma tumor growth in vivo by survivin targeting

A role of apoptosis (programmed cell death) in tumor formation and growth was investigated by targeting the apoptosis inhibitor survivin in vivo. Expressio...

Grossman，D. - 《Proceedings of the National Academy of Sciences of the United States of America》

PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy

The PTEN tumor suppressor protein inhibits phosphatidylinositol 3-kinase (PI3K)/Akt signaling that promotes translocation of Mdm2 into the nucleus. When re...

LD Mayo，JE Dixon，DL Durden，... - 《Journal of Biological Chemistry》

Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma

The newly described apoptosis inhibitor survivin is expressed in many human cancers and appears to play a critical part in both apoptosis regulation and ce...

Douglas，Grossman，Jennifer，... - 《Journal of Investigative Dermatology》

Apoptosis-regulating proteins as targets for drug discovery.

Defects in the regulation of apoptosis (programmed cell death) contribute to many diseases, including pathologies associated with cell loss (e.g. stroke, h...

JC Reed - 《Trends in Molecular Medicine》