摘要：

The possible formation of N-nitroso compounds in vivo from ingested secondary or tertiary amines and nitrite was tested with 13 amino compounds selected on the basis of their widespread availability to man. The amino compounds were administered to rats in the drinking-water with or without sodium nitrite. Survival rates differed little between the various groups and only a few of the amines, either alone or in combination with nitrite, induced a significant incidence of malignant tumours. Lucanthone gave rise to a 30% incidence of liver tumours when given alone but not when given in combination with nitrite. Chlordiazepoxide plus nitrite induced nervous system tumours in 10% of the animals, methapyrilene plus nitrite induced liver tumours in 30%, and dimethyldodecylamine plus nitrite induced tumours of the urinary bladder in 10% of the treated rats. These results provide further evidence that ingestion of secondary and tertiary amines together with nitrite can lead to the formation of significant amounts of carcinogenic N-nitroso compounds in the stomach.

展开