摘要：

The demonstration that nalorphine is a potent nonaddicting analgesic in man stimulated a search among other narcotic antagonists for potent analgesics without the psychotomimetic effects of nalorphine. Most recently a series of benzomorphan derivatives capable of antagonizing meperidine analgesia in animals was surveyed in man for analgesic activity and psychotomimetic effects. Of the six derivatives studied, two were shown to have the desired characteristics of potent analgesia without psychotomimetic effects. To date, one of these has also been shown to be without addiction liability of the narcotic type in man. The study of these benzomorphan derivatives permitted correlations to be drawn among analgesia, narcotic antagonism, psychotomimetic effects, respiratory depression, and addiction liability.

展开