Mitochondrial respiratory chain activity in the human brain as a function of age.

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作者：

J Ojaimi，C Masters，K Opeskin，P Mckelvie，E Byrne

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摘要：

Age-associated changes in mitochondrial respiratory chain activity were investigated in brain tissue collected at autopsy. Four brain regions, the frontal cortex, superior temporal cortex, cerebellum and putamen, were studied to map any regional variation. A significant decrease in oxidase activity was seen in all regions studied with increasing age (P<0.05). Although a small decrease in succinate dehydrogenase-oxidoreductase and : was observed, this was not statistically significant. This study has shown that the age-related fall in oxidase activity affects the frontal cortex, superior temporal cortex, cerebellum and putamen. The variation in the extent of age-related decline was striking. We hypothesize that individuals with more severe age-related decline may be predisposed to neuronal dysfunction, whereas individuals with well preserved may enjoy some degree of neuronal protection.

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关键词：

human brain ageing mitochondria respiratory activity cytochrome c oxidase

DOI：

info:doi/10.1016/S0047-6374(99)00071-8

被引量：

188

年份：

1999