Resistance of Human Leukemic and Normal Lymphocytes to Drug-induced DNA Cleavage and Low Levels of DNA Topoisomerase II
摘要：
Adriamycin, amsacrine, and etoposide produce protein-associated DNA breaks in numerous cell types. However, exposure to Adriamycin (0.1–50.0 µg/ml) resulted in no detectable DNA cleavage in lymphocytes from patients with B-cell chronic lymphocytic leukemia (CLL) or in either B- or T-lymphocytes from normal donors. In contrast, DNA cleavage was observed in T-cells from CLL patients. Exposure to amsacrine or etoposide caused at least 50-fold less DNA cleavage in CLL and normal lymphocytes as compared to L1210 cells. These findings cannot be accounted for by differences in drug uptake.
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DOI：
doi:10.1007/BF01517001
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年份：
1988
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来源期刊
Cancer Research
6/15/1988
引用走势
2010
被引量：107
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