Chemical characterization and antifungal activity of Cinnamomum camphora essential oil

来自 dx.doi.org

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作者：

VS Pragadheesh，A Saroj，A Yadav，CS Chanotiya，M Alam，A Samad

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摘要：

Chiral compounds have shown antimicrobial activity, enantioselectively. Leaf oil composition of Cinnamomum camphora was studied using GC-FID, SPME-GC-FID, enantio-GC and GC/MS techniques. Camphor exists in two chiral forms and contributes major percentage to C. camphora essential oil (68.4–81.2%). The results showed (1R)-(+)-camphor as major enantiomer (ee>99%). The biological potential of essential oil, (1R)-(+)- and (1S)-()-camphor was investigated against Choanephora cucurbitarum, a Withania wet rot pathogen. The activity was evaluated against fungal growth and morphological changes in the hyphae of C. cucurbitarum, after 18, 21 and 24h of treatments. A significant growth inhibition in C. cucurbitarum was observed against (1R)-(+)-camphor. Further, in comparison to (1R)-(+)-camphor, C. camphora oil revealed better activity. Fungal growth inhibition by (1R)-(+)-camphor and plant essential oil was due to cytoplasm coagulation and hyphal lysis of C. cucurbitarum. Moreover, C. camphora essential oil could be used in the preparation of strong fungistatic agent against C. cucurbitarum infection.

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关键词：

Practical/ essential oils/ chemical characterization antifungal activity Cinnamomum camphora essential oil chiral compounds antimicrobial activity enantioselectively leaf oil composition SPME-GC-FID technique enantio-GC technique GC/MS technique enantiomer biological potential 1R)-(+)-camphor (1S)-(-)-camphor morphological changes hyphae fungal growth inhibition cytoplasm coagulation hyphal lysis fungistatic agent C. cucurbitarum infection time 18 h time 21 h time 24 h/ E3626 Chemical industry E1780 Products and commodities/ time 6.48E+04 s time 7.56E+04 s time 8.64E+04 s