Biodegradable long-circulating polymeric nanospheres

Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, ho...

R Gref，Y Minamitake，M Peracchia，... - 《Science》

In vitro and in vivo biologic evaluation of long-circulating biodegradable drug carriers loaded with the pure antiestrogen RU 58668.

We have developed a parenteral delivery system for the administration of the highly promising pure antiestrogen RU 58668 (RU). Two types of nanoparticles (...

T Ameller，V Marsaud，P Legrand，... - 《International Journal of Cancer》

In vitro and in vivo biologic evaluation of long-circulating biodegradable drug carriers loaded with the pure antiestrogen RU 58668

We have developed a parenteral delivery system for the administration of the highly promising pure antiestrogen RU 58668 (RU). Two types of nanoparticles (...

Thibault，Ameller，Véronique，... - 《International Journal of Cancer》

Biodegradable PEGylated microspheres and nanospheres

Therefore an agent is needed that can provide a chemical camouflage to these microspheres and nanospheres in order to make them long-circulating carriers. ...

VR Sinha，A Aggarwal，A Trehan - 《American Journal of Drug Delivery》

Biodegradable PEGylated Microspheres and Nanospheres

to make them long-circulating carriers.Polyethylene glycol (PEG), a hydrophilic, US FDA-approved polymer, provides the solution to this difficult problem. ...

VR Sinha，A Aggarwal，A Trehan - 《American Journal of Drug Delivery》

'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of t...

These results could be useful in the design of long circulating intravenously injectable biodegradable drug carriers endowed with protein resistant properties and...

R Gref a，M Lück b，P Quellec c，... - 《Colloids Surf B Biointerfaces》

The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres

The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheresLong-circulatingnanoparticlesBiodegradable

R.，Gref，and，... - 《Advanced Drug Delivery Reviews》

The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres

Long-circulating nanoparticlesBiodegradable polymersPolyethylene glycolHydrophilic coatingReduced liver accumulationIntravenous drug administration...

R. Gref and A. Domb and P. Quellec and T. Blunk and R.H. Müller and J.M. Verbavatz and R. Langer - 《Advanced Drug Delivery Reviews》

'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption.

These results could be useful in the design of long circulating intravenously injectable biodegradable drug carriers endowed with protein resistant properties and low phagocytic uptake.doi:10.1016/S0927-7765(99)00156-3Gref...

Gref，Lück，Quellec，... - 《Colloids & Surfaces B Biointerfaces》