Non-invasive administration of drugs through the skin: challenges in delivery system design
摘要：
Vehicles designed to enhance drug delivery through the skin must incorporate specific elements that improve the ability of the delivery system to overcome the barrier posed by the stratum corneum. This review discusses several chemical penetration enhancers that have been investigated as potential tools to increase drug flux. In addition, lipid-based delivery systems offer an attractive alternative to traditional drug vehicles. The relationship between liposome composition and drug permeation is discussed, in addition to the possible mechanism of action of lipid vesicle-mediated drug delivery.
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关键词：
Skin Drug delivery Skin hydration Elasticity Permeability Formulations Topical Dermal Transdermal Liposomes
DOI：
10.1016/S1461-5347(00)00317-5
被引量：
年份：
2000
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