Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.
摘要：
We investigated alterations in the structure and expression of oncogenes in mammary tumors and mammary tumor-derived cell lines. In 16 of 95 samples, we detected amplification of the human neu oncogene, also known as c-erB-2, accompanied by overexpression in the tumors from which intact RNA could be isolated. In 10 of these DNAs, the linked oncogene c-erbA was also amplified, whereas another gene on human chromosome 17, p53, was present in normal copy numbers. Overexpression of c-erbA could not be detected in the tumors analyzed. The relatively high frequency of neu amplification points to a functional role in human breast cancer. Coamplification of the c-erbA oncogene could contribute to this disease as well but is most likely fortuitous.
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关键词：
Cell Line Chromosomes, Human, Pair 17 Humans Breast Neoplasms Lymphatic Metastasis Thyroglobulin Neoplasm Proteins Proto-Oncogene Proteins Phosphoproteins Receptors, Estrogen
DOI：
10.1128/MCB.7.5.2019
被引量：
年份：
1987
掌桥科研
万方医学
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