The first direct and enantioselective cross-aldol reaction of aldehydes.
摘要：
The first enantioselective catalytic direct cross-aldol reaction that employs nonequivalent aldehydes has been accomplished using proline as the reaction catalyst. Structural variation in both the aldol donor (R1 = Me, n-Bu, Bn, 91 to >99%) and aldol acceptor (R2 = I-Pr, I-Bu, c-C6H11, Et, Ph, 97-99% ee) are possible while maintaining high reaction efficiency (75-88% yield). Significantly, this new aldol variant allows facile enantioselective access to a broad range of beta-hydroxy aldehydes which are valuable intermediates in polyketide syntheses.
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关键词：
diastereoselective syntheses, enantioselective syntheses (incl. ci/trans‐isomerism aldehyde derivatives (acyclic compounds aldehyde derivatives (benzene compounds
DOI：
10.1002/chin.200242037
被引量：
年份：
2002
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掌桥科研
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