摘要：

Transgenic CBA (H-2^k haplotype) mice expressing the H-2 K^b major histocompatibility complex (MHC) class I gene under control of transcriptional promoter elements from a milk protein gene display high-level H-2 K^b transcription in lactating mammary glands and low-level transcription in skin and thymus of male and virgin female transgenic mice. However, H-2 K^b antigen could be detected only in lactating mammary gland epithelial cells by immunohistological methods. All transgenic mice are tolerant of H-2 K^b since they fail to reject skin grafts from mice expressing H-2 K^b molecules. Furthermore, anti-H-2 K^b cytotoxic responses could not be generated using responder T cells from transgenic mice but T cells from the same mice proliferated, in the presence of interleukin-2, in response to stimulator cells expressing H-2 K^b. Tolerance to H-2 K^b is induced in the thymus since CBA mice grafted wit

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