摘要：

Background Although widely applied, the cost-effectiveness of endovenous laser ablation (EVLT) for varicose veins has not been established. Methods Cost-effectiveness analysis was performed on the evaluation of EVLT for the treatment of uncomplicated varicose veins by using published data from randomizd clinical trials regarding the costs and the quality of life. Incremental cost per quality-adjusted life year (QALY) gained at 6months following treatment was calculated. Sensitivity analysis was carried out to investigate the uncertainty associated with the results of our analysis. Results Over the time horizon of 1???6months, it was found that the incremental cost of EVLT compared with conventional surgery was ???466.66 and the incremental effect was ???0.007 QALY at 1month, ???0.0075 QALY at 3months and 0.0 QALY at 6months. This shows that the strategy ???EVLT??? was dominated by the strategy ???HL/S??? at any time point for the base cases analyses. The results of various alternative economic evaluations indicated that EVLT may be a potentially cost effective (i.e. incremental cost effectiveness ratio of between ???12158.67 and ???514721.67 per QALY, respectively) treatment option compared to conventional surgical treatment for varicose veins with a certainty between 54.9 and 98.8%. Conclusion For patients with uncomplicated varicose veins and evidence of saphenofemoral reflux, surgical treatment for varicose veins offers a robust health benefit for relatively less costs compared to EVLT.

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