A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
摘要：
The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase.
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关键词：
Hela Cells Humans Escherichia coli Acetyltransferases Cell Cycle Proteins Trans-Activators Saccharomyces cerevisiae Proteins Adenovirus E1A Proteins Nuclear Proteins Recombinant Fusion Proteins
DOI：
10.1038/382319a0
被引量：
年份：
1996
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万方医学
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