The rab GTPase family
摘要：
The Rab family is part of the Ras superfamily of small GTPases. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they function as regulators of distinct steps in membrane traffic pathways. In the GTP-bound form, the Rab GTPases recruit specific sets of effector proteins onto membranes. Through their effectors, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion.
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关键词：
Amino Acid Sequence Animals Evolution, Molecular Humans Intracellular Membranes Models, Biological Molecular Sequence Data Mutation Phylogeny Protein Conformation
DOI：
10.1186/gb-2001-2-5-reviews3007
被引量：
年份：
2001
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