A review of the application of lipid-based systems in systemic, dermal/ transdermal, and ocular drug delivery.

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摘要：

The introduction of combinatorial chemistry and the development of high-throughput techniques has significantly increased the amount of new active lipophilic molecular entities. As a result, the need for successful delivery of these lipophilic active compounds has also increased. One such method of delivery is through the use of advanced lipid-based drug delivery systems. Traditionally, the majority of reviews of lipid-based drug delivery systems were based on the oral administration field only. This review article focuses on the use of lipids in parenteral, dermal/ transdermal, and ocular drug delivery systems. Specific needs, considerations, approaches, and limitations in lipid-based drug delivery are discussed herein on the basis of the anatomical and physiological diversity of the target organs and systems.

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关键词：

liposome micelle emulsion solid-lipid nanoparticle lipid-based formulations lipid excipients ocular drug delivery dermal/transdermal drug delivery