摘要：

where A 3 is A 2 or a polymer, where A 3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halides, aryl, imidazoyl, carbonyl, carboxy, thiol or a residue comprising an activated carbon; --X-- is selected from the group consisting of ##STR1## --R 1 -- is ##STR2## or a C 1 -C 10 branched or unbranched alkyl or aralkyl, which may be substituted by --OH; --Y-- is a direct bond to --E--, or --Y-- is --E--R 2 -- where R 2 is a C 1 -C 10 branched or unbranched alkyl; Z a is chlorine, bromine or iodine; E is O, NH or an acyclic divalent sulfur atom; Det b is a chemical moiety capable of being detected, preferably comprising biotin or a metal chelator of the formula: ##STR3## or the 4-hydroxy or acyloxy derivative thereof, where R 3 is C 1 -C 4 alkyl or CH 2 COOM, M is the same or different and selected from the group consisting of hydrogen, a metal or non-metal cation or is C 1 -C 10 alkyl, aryl or aralkyl; and m is an integer from 1 to the total number of modified reactive groups on A 3 . The detectable molecules are useful in in virto or in vivo assays or therapy.

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