摘要：

The present study was undertaken to investigate the sedative, analgesic and clinical effects of xylazine, medetomidine and dexmedetomidine with fentanyl as pre-anaesthetics in water buffaloes and to compare the dose-sparing effect of xylazine, medetomidine and dexmedetomidine on thiopental for induction and isoflurane for maintenance of anaesthesia in water buffaloes. Six male water buffaloes randomly received intravenous fentanyl (. g/kg body weight) and xylazine (. mg/kg body weight), fentanyl (. g/kg body weight) and medetomidine (. g/kg body weight), fentanyl (. g/kg body weight) and dexmedetomidine (. g/kg body weight) at weekly intervals in groups I, I and I, respectively. Aftermin, the animals were restrained in right lateral recumbency and anaesthesia was induced by % thiopental sodium administered intravenously. The intubated animal was connected to the large animal anaesthesia machine and isoflurane in % oxygen ( L/min) was insufflated formin. The treatments were compared by clinicophysiological, haematobiochemical and haemodynamic parameters. Fentanyl-medetomidine and fentanyl-dexmedetomidine produced more cardiovascular depression during the pre-anaesthetic period but less depression of cardio-respiratory dynamics in the post induction and maintenance period. Quicker recovery was recorded in I and I groups. A lower dose of thiopental was required in group I (. mg/kg. mg/kg) than in groups I (. mg/kg. mg/kg) and I (. mg/kg. mg/kg). The dose of isoflurane was less in group I (. mL. mL) than in group I and I (. mL. mL and . mL. mL). Better anaesthesia was recorded with fentanyl-dexmedetomidine-thiopental-isoflurane (group I) than with fentanyl-medetomidine-thiopental-isoflurane (group I) and fentanyl-xylazine-thiopental-isoflurane (group I). Fentanyl-medetomidine and fentanyl-dexmedetomidine were better pre-anaesthetic agents in comparison to fentanyl-xylazine for thiopental and isoflurane anaesthesia. Fentanyl-dexmedetomidine-thiopental-isoflurane and fentanyl-medetomidine-thiopental-isoflurane produced effective surgical anaesthesia and were found to be safe, as cardio-pulmonary functions were well preserved during maintenance anaesthesia with no deleterious effect on vital organ functions in water buffaloes.

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