Short echo time proton MR spectroscopic imaging.

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作者：

S Posse，B Schuknecht，ME Smith，PCM Van Zijl，N Herschkowitz，CTW Moonen

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摘要：

Proton spectroscopic imaging at short TEs (20-30 ms) in human brain requires volume preselection inside the brain to suppress overwhelming lipid and water signals from surrounding tissue. In this article we discuss limitations of conventional volume preselection using stimulated echoes that lead to spectral contamination from surrounding tissue. Improved volume preselection was obtained by adding a complete outer volume suppression (presaturation). The performance of the method is illustrated on normal volunteers and on clinical cases with brain tumors and multiple sclerosis (MS) plaques. In normal human brain, we detected resonances with short T2 values and complex J-coupling, including rather broad methyl/methylene resonances in the chemical shift range between 0 and 2 ppm. Spectroscopic images obtained on patients with intracranial tumors and on one patient with several MS plaques demonstrate the possibility of detecting regional distributions of increased methyl/methylene resonances between 0 and 2 ppm in brain lesions.

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关键词：

Bibliography, Practical, Experimental/ biomedical NMR brain nuclear magnetic resonance spectroscopy proton magnetic resonance/ medical diagnostic imaging short echo time proton MR spectroscopic imaging multiple sclerosis plaques lipid signals methyl resonance methylene resonance water signals stimulated echoes outer volume suppression presaturation normal volunteers clinical cases brain tumors normal human brain short T2 values complex J-coupling chemical shift intracranial tumors 20 to 30 ms/ A8760G Microwaves and other electromagnetic waves (medical uses) A8770E Patient diagnostic methods and instrumentation A8730 Biophysics of neurophysiological processes A8740 Biomagnetism/ time 2.0E-02 to 3.0E-02 s