The Resolution of Inflammation

来自 Springer

阅读量:

29

作者:

G Bellingan

展开

摘要:

Inflammation requires clearance of the inciting pathogen, then orchestrated removal of the burden of leukocytes and other cells influxed into the inflamed site along with dissipation of the pro (or anti) inflammatory mediator cascades. We now recognize that this resolution process is strictly controlled by a number of mediators and adhesion molecules. Apoptotic cell death, when timed appropriately, allows the non-phlogistic clearance of PMNs, monocytes and eosinophils. Macrophage engulfment of these apoptotic cells signals further anti-inflammatory processes, including additional programmed cell death, anti-inflammatory mediator release, and promotes active macrophage emigration which is the final route by which cell clearance is effected. Should these processes evolve successfully, then the tissue will return to its normal structure and function, but should this not proceed effectively then the body will limit further damage by evoking a fibrotic response to 'heal and seal' the damaged tissue.

展开

DOI:

10.1007/978-3-7643-7506-5

被引量:

30

年份:

2008

通过文献互助平台发起求助,成功后即可免费获取论文全文。

相似文献

参考文献

引证文献

研究点推荐

引用走势

2011
被引量:7

站内活动

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

关于我们

百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的学术服务。在这里我们保持学习的态度,不忘初心,砥砺前行。
了解更多>>

友情链接

百度云百度翻译

联系我们

合作与服务

期刊合作 图书馆合作 下载产品手册

©2025 Baidu 百度学术声明 使用百度前必读

引用