Murine psoriasis-like disorder induced by naive CD4+ T cells
摘要：
Psoriasis is a complex disorder involving alterations of many cell types. Although evidence suggests a T-cell pathogenesis for psoriasis, a primary role of T cells has not been directly demonstrated. Here, we show that reconstitution of scid/scid mice with minor histocompatibility mismatched naive CD4+ T lymphocytes resulted in skin alterations that strikingly resembled human psoriasis clinically, histopathologically and in cytokine expression. This skin disorder was diminished when memory T cells were coinjected. Thus, a subset of dysregulated CD4+ T cells can cause tissue alterations seen in psoriasis without the presence of CD8+ cells or a primary epithelial abnormality.
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Humans Exercise Blood Pressure Heart Rate Vasodilation Physical Endurance Running Adult Arteries Female
DOI：
10.1038/nm0297-183
被引量：
年份：
1997
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