Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

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116

作者：

F Sallusto，CR Mackay，A Lanzavecchia

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摘要：

There is growing evidence that T helper cell subsets (T$_H$1 and T$_H$2) can be differentially recruited to promote different types of inflammatory reactions. Murine T$_H$1 but not T$_H$2 cells are recruited through P- and E-selectin into inflamed tissues, where they induce delayed-type hypersensitivity reactions. The human eotaxin-receptor CCR3, originally described on eosinophils and basophils, was also found to be expressed by T$_H$2 cells. An antibody to CCR3 was used to isolate T cells from peripheral blood that give rise to T$_H$2-polarized cell lines and to identify T$_H$2 cells derived from naive T cells in vitro. Eotaxin stimulated increases in intracellular calcium and chemotaxis of CCR3$^+$ T cells. The attraction of T$_H$2 cells by eotaxin could represent a key mechanism in allergic reactions, because it promotes the allergen-driven production of interleukin-4 and interleukin-5 necessary to activate basophils and eosinophils.

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关键词：

Adult Calcium metabolism Cell Line Cell Separation Chemokines CC Chemotaxis Leukocyte Clone Cells Cytokines metabolism pharmacology Humans Interferon Type II biosynthesis Interferon-alpha pharmacology Interleukin-3 biosynthesis Interleukin-4 biosynthesis Receptors Chemokine Receptors Cytokine metabolism Research Support Non-U.S. Gov't Th2 Cells metabolism physiology Transforming Growth Factor beta pharmacology