Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.
阅读量：
43
摘要：
Anti-DNA antibodies, specifically those that stain nuclei in a homogenous nuclear (HN) fashion, are diagnostic of systemic lupus erythematosus (SLE) and the MRL-lpr/lpr SLE murine model. We have used a heavy chain transgene that increases the frequency of anti-HN antibodies to address whether their production in SLE is the consequence of a defect in B cell tolerance. Anti-HN B cells were undetectable in nonautoimmune-prone transgenic mice, but in MRL-lpr/lpr transgenic mice their Ig was evident in the sera and they were readily retrievable as hybridomas. We conclude that nonautoimmune animals actively delete anti-HN-specific B cells, and that MRL-lpr/lpr mice are defective in this process possibly because of the lpr defect in the fas gene.
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关键词：
CHEMILUMINESCENCE IMMUNOMETRIC ASSAY PHTHALHYDRAZIDES ACRIDINIUM ESTERS ENZYME IMMUNOASSAY RANDOM ACCESS ANALYSIS SCREENING ASSAYS
DOI：
10.1084/jem.181.3.1157
被引量：
年份：
1995
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