Cell specificity for the pulmonary metabolism of tobacco-specific nitrosamines in the Fischer rat.

The activity and distribution of the metabolic pathways of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), its major metabolite 4-(methylnitrosamino)...

SA Belinsky，CM White，T Neil，... - 《Carcinogenesis》

Photochemical transformations of small ring carbonyl compounds. XVIII. Deuterium isotope effects in the photochemistry of an azetidine ketone

We selected 63 prostate tumors with Gleason's grade 6 (3+3), commonly showing both tubular and cribrous patterns. We compared in both patterns the expressi...

A Padwa，R Gruber - 《Journal of the American Chemical Society》

DNA damage by carbonyl stress in human skin cells

Reactive carbonyl species (RCS) are potent mediators of cellular carbonyl stress originating from endogenous chemical processes such as lipid peroxidation ...

MJ Roberts，GT Wondrak，DC Laurean，... - 《Mutat Res》

Mitochondrial Dysfunction Leads to Deconjugation of Quercetin Glucuronides in Inflammatory Macrophages

Dietary flavonoids, such as quercetin, have long been recognized to protect blood vessels from atherogenic inflammation by yet unknown mechanisms. We have ...

A Ishisaka，K Kawabata，S Miki，... - 《Plos One》

Organic and conventional Coffea arabica L.: a comparative study of the chemical composition and physiological, biochemical and toxicological effects in Wis...

Differentiation between organic and conventional coffee has increased due to the growing demand and high consumption of healthy foods that contain compound...

DDC Carvalho，Maisa Ribeiro Pereira Lima Brigagão，MHD Santos，... - 《Plant Foods Hum Nutr》

Chalcone Derivatives Inhibit Glutathione S-Transferase P1-1 Activity: Insights into the Interaction Mode of , β-Unsaturated Carbonyl Compounds

et al.Chalcone derivatives inhibit glutathione s-transferase P1-1 activity: insights into the interaction mode ofα,β-unsaturated carbonyl compounds.Chem Biol...

J Wang，S Wang，D Song，... - 《Chemical Biology & Drug Design》

Carcinogenicity of Nickel: A Review

Nickel is well known for its wide industrial and chemical applications. It is naturally found in environment (air, water and soil) at low levels. But throu...

V Vishwakarma，S Kumar，B Yadav，... - Emerging Trends and Challenges in Biosciences

Two electrophilic dietary phytochemicals suppress cyclooxygenese-2 expression in macrophages via contrastive molecular mechanisms

Both ZER and HOA carry an 伪,尾-unsaturated carbonyl moiety that is potentially susceptible to conjugation with biological nucleophiles, implying that each suppresses COX-2 induction through the regulation of redox-sensitive molecules. The ...

A Murakami，T Nishizawa，T Shigemori，... - 《Cancer Research》

Determination of chemical substances in mainstream of Japanese cigarettes.

Japan executed the tobacco control program under the Framework Convention on Tobacco Control (FCTC) in 2005. However, after the program was carried out, sc...

Y Inaba，S Uchiyama - 《Journal of the National Institute of Public Health》