Nuclear PI(4,5)P(2): a new place for an old signal.

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摘要：

Over the last decades, evidence has accumulated suggesting that there is a distinct nuclear phosphatidylinositol pathway. One of the best examined nuclear lipid pathways is the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI4,5P 2) by PLC resulting in activation of nuclear PKC and production of inositol polyphosphates. However, there is a growing number of data that phosphoinositides are not only precursor for soluble inositol phosphates and diacylglycerol, instead they can act as second messengers themselves. They have been implicated to play a role in different important nuclear signaling events such as cell cycle progression, apoptosis, chromatin remodeling, transcriptional regulation and mRNA processing. This review focuses on the role of specifically PI4,5P 2 in the nucleus as a second messenger as well as a precursor for PI3,4,5P3, inositol polyphosphates and diacylglycerol.

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关键词：

Phosphatidylinositol 4,5-bisphopshate Phospholipase C Diacylglycerol Cell cycle Chromatin remodeling Nuclear speckle

DOI：

10.1016/j.bbalip.2006.03.002

被引量：

169

年份：

2006