PET imaging The experiment was divided over 2 days. On the first day, all animals received a saline injection (0.1 ml/10 g i.p.) and, immediately afterwards, 29–37 MBq 2-[18F]fluoro-2-

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WA TissueI AnalyserMünsterwas used

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References1. Rinaldi-Carmona M, Barth F, Millan J et al (1998) SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor. J Pharmacol Exp Ther 284:644- 6502. Portier M, Rinaldi-Carmona M, Pecceu F et al. (1999) SR 144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist. J Pharmacol Exp Ther 288:582-5893. Barth F, Rinaldi-Carmona M (1999) The development of cannabinoid antagonists. Curr Med Chem 6:745-7554. Di Marzo, V. (2008) Targeting the endocannabinoid system: To enhance or reduce? Nat Rev Drug Discov 7:438-4555. Iwamura H, Suzuki H, Ueda Y et al. (2001) In vitro and in vivo pharmacological characterization of JTE-907, a novel selection ligand for cannabinoid CB2 receptor. J Pharmacol Exp Ther 296:420-4256. Wright KL, Duncan M, Sharkey KA (2008) Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation. Br J Pharmacol 153:263-270

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