摘要：

OBJECTIVE:To summarize the research advancement of the relationship between nonresolving inflammation and epithelial-mesenchymal transition in tumor,and discuss the role and probable mechanism of nonresolving inflammation in malignant transition of tumor cells.METHODS: By PubMed and CNKI retrieval system,with "epithelial-mesenchymal transition(EMT),nonresolving inflammation and tumor microenvironment" as Key words:,papers from 2005-01 to 2010-12 were obtained.Twenty-six papers of literature are selected and analyzed according to the inclusion criteria as follows: 1)The relationship between nonresolving inflammation and tumor;2)The relationship between nonresolving inflammation and EMT;3)Mechanisms of EMT regulated by nonresolving inflammation.RESULTS: In nonresolving inflammatory status,inflammatory cytokines such as TGF-β,TNF-α and ILs can initiate and maintain the EMT process of tumor cells,which enhances their invasive and migratory ability,by activating the transcription factors associated with EMT through NF-κB signaling pathway.Furthermore,EMT promotes construction of the inflammatory tumor microenvironment.CONCLUSIONS: Nonresolving inflammation and EMT are tightly related in tumor,and inhibition of EMT through targeting the key components of the Nonresolving Inflammation-EMT signaling network probably be novel strategies for the prevention and treatment of tumor in the future.

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