摘要：

Apaf, apoptosis protease activation factor; CAD, caspase-activated DNAse; caspase, cysteine aspartate-directed protease; CAPK, ceramide-activated protein kinase; CARD, caspase recruitment domain; c-IAP, inhibitor of cellular apoptosis; cPLA[sub 2], cytosolic phospholipase A[sub 2]; DcR, decoy receptor; DD, death domain; DED, death effector domain; DIF, differentiation inducing factor; DISC, death-inducing signalling complex; DR, death receptor; EDG, endothelial differentiation gene; FADD, Fas-associated DD; FAN, factor associated with neutral sphingomyelinase activation; FLICE, FADD-like interleukin-converting enzyme; FLIP, FLICE-like inhibitory protein; IκB, inhibitor of κB; IκK, IκB kinase; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; LT, lymphotoxin; MADD, MAPK-activating DD protein; MAPK, mitogen-activated protein kinase; MEK, MAPK kinase; MEKK, MEK kinase; mTNF, membrane-bound TNF; NIK, NF-κBinducing kinase; NF-κB, nuclear factor-κB; PARP, polyadenosine ribosyl polymerase; RIP, receptor-interacting protein; PKA, cyclic AMP-dependent protein kinase; PKB, Akt/protein kinase B; PKC, protein kinase C; PLAD, pre-ligand assembly domain; ROS, reactive oxygen species; S-l-P, sphingosine-l-phosphate; SAPK, stress-activated protein kinase; SODD, silencer of DD; TACE, TNF-α converting enzyme; TNF, tumour necrosis factor-α; TNFR, TNF receptor; TNFR1, type I 55 kDa TNFR; TNFR2, type II 75 kDa TNFR; TNFSF, TNF superfamily nomenclature; TNFRSF, TNFR superfamily nomenclature; TRADD, TNFRassociated DD; TRAF, TNFR-associating factor; TRAK, TNFR-associated kinase.

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