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Rapid evolution of expression and regulatory divergences after yeast gene duplication

来自 Semantic Scholar

阅读量：

44

作者：

X.，Gu，Z.，Zhang，W.，Huang

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摘要：

Although gene duplication is widely believed to be the major source of genetic novelty, how the expression or regulatory network of duplicate genes evolves remains poorly understood. In this article, we propose an additive expression distance between duplicate genes, so that the evolutionary rate of expression divergence after gene duplication can be estimated through phylogenomic analysis. We have analyzed yeast genome sequences, microarrays, and transcriptional regulatory networks, showing a >10-fold increase in the initial rate for both expression and regulatory network evolution after gene duplication but only an 20% rate increase in the early stage for protein sequences. Based on the estimated age distribution of yeast duplicate genes, we roughly estimate that the initial rate of expression divergence shortly after gene duplication is 2.9 × 10-9 per year, whereas the baseline rate for very ancient gene duplication is 0.14 × 10-9 per year. Relative expression rate tests suggest that the expression of duplicate genes tends to evolve asymmetrically, that is, the expression of one copy evolves rapidly, whereas the other one largely maintains the ancestral expression profile. Our study high- lights the crudal role of early rapid evolution after gene/genome duplication for continuously increasing the complexity of the yeast regulatory network.

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关键词：

Gene Duplication regulatory Yeasts Evolution network 基因复制 酵母菌 进化

DOI：

10.1073/pnas.0409186102

被引量：

325

年份：

2005

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来源期刊

Proceedings of the National Academy of Sciences
2005年01月12日

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2007
被引量：33

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