Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking
摘要：
Glycosyl-phosphatidylinositol (GPI)-anchored proteins have been reported to reside in clusters collected over small membrane invaginations called caveolae. The detection of different GPI-anchored proteins with fluorescently labeled monoclonal antibodies showed that these proteins are not constitutively concentrated in caveolae; they enter these structures independently after cross-linking with polyclonal secondary antibodies. Analysis of the cell surface distribution of the GPI-anchored folate receptor by electron microscopy confirms these observations. Thus, multimerization of GPI-anchored proteins regulates their sequestration in caveolae, but in the absence of agents that promote clustering they are diffusely distributed over the plasma membrane.
展开
DOI：
10.1126/science.7516582
被引量：
年份：
1994
Taylor & Francis
Wiley
万方医学
Semantic Scholar
dx.doi.org
查看更多
JSTOR
Europe PMC
NCBI
NCBI
JBC
adsabs.harvard.edu
dialnet.unirioja.es
ProQuest
ResearchGate
mendeley.com
cghjournal.org
jlr.org
jcs.biologists.org
readcube.com
onAcademic
sciencemag.org
atvb.ahajournals.org
scienceopen.com
jcb.rupress.org
www.socolar.com
iai.asm.org
molbiolcell.org
emboj.embopress.org
biochemsoctrans.org
ajpendo.physiology.org
highbeam.com
jimmunol.org
fasebj.org
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
