Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
摘要：
Human chronic myelogenous leukaemia is characterized by a reciprocal translocation between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and the transfer of the abl cellular oncogene from chromosome 9 into the bcr gene of chromosome 22. Characterization of an 8-kilobase RNA specific to chronic myelogenous leukaemia shows it to be a fused transcript of the two genes. The fused protein that would be produced is probably involved in the malignant process.
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关键词：
Humans Leukemia, Myeloid DNA Restriction Enzymes DNA, Neoplasm Cloning, Molecular Nucleic Acid Hybridization Base Sequence Oncogenes Transcription, Genetic
DOI：
10.1038/315550a0
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年份：
1985
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