Stimulation-induced uptake and release of zinc in hippocampal slices.

来自 EBSCO

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摘要：

The mossy-fibre axons of the hippocampus form a dense plexus, uniquely rich in chelatable zinc 1–3 . Because the metal is apparently concentrated within the terminal bags of the axons 4,5 , it has been hypothesized that the zinc is involved in mossy-fibre synaptic transmission 6,7 . Although some electrophysiological findings 8,9 have favoured the hypothesis, neither preferential uptake of zinc into the hippocampus 10,11 nor depolarization-induced release of zinc from hippocampal tissue 12 has previously been found. Using the hippocampal slice preparation, we now report that the mossy-fibre neuropil and cells of origin (dentate granule cells) take up zinc preferentially and that electrical stimulation selectively facilitates both uptake of exogenous zinc into mossy-fibre neuropil and release of previously incorporated 65 Zn from the tissue. The results suggest that the role of zinc in mossy-fibre axons is dynamically linked to neural signalling processes.

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关键词：

Animals Rats Hippocampus Pyramidal Tracts Calcium Magnesium Zinc Electric Stimulation Biological Transport Evoked Potentials