Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid |[beta]| protein precursor

来自 NCBI

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作者：

W Wasco，S Gurubhagavatula，MD Paradis，DM Romano，SS Sisodia，BT Hyman，RL Neve，RE Tanzi

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摘要：

Familial Alzheimer's disease (FAD) is a genetically heterogeneous disorder that includes a rare early-onset form linked to mutations in the amyloid b protein precursor (APP) gene. Clues to the function of APP derive from the recent finding that it is a member of a highly conserved protein family that includes the mammalian amyloid precursor-like protein (APLP1) gene which maps to the same general region of human chromosome 19 linked to late-onset FAD. Here we report the isolation of the human APLP2 gene. We show that APLP2 is a close relative of APP and exhibits a very similar pattern of expression in the brain and throughout the body. Like APP, APLP2 contains a cytoplasmic domain predicted to couple with the GTP-binding protein G(o) indicating that it may be an additional cell surface activator of this G protein.

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关键词：

eukaryotic initiation factor gene transcription antisense DNA

DOI：

10.1038/ng0993-95

被引量：

2101

年份：

1993