Stereoselective Synthesis of (-)-Cytoxazone and (+)-5-Epi-cytoxazone.
摘要：
A novel, stereo selective synthesis of ()-cytoxazone 1a and stereoselective synthesis of (+)-5-epi-cytoxazone 1b were achieved via stereoselective Grignard addition of vinylmagnesium bromide on N-Boc al ehyde obtained from p-hydroxy-d-phenylglycine 2 followed by cyclization of N-Boc alcohol 6, ozonolysis and reduction to get (+)-5-epi-cytoxazone. Compound 6 underwent mitsunobu conditions, deprotection of ester followed by cyclization of N-Boc alcohol to get ()-cytoxazone. #IICT Communication Number:020616. #IICT Communication Number:020616.
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关键词：
other bioactive products diastereoselective syntheses, enantioselective syntheses (incl. cis/trans-isomerism C-C bond formation
DOI：
10.1081/SCC-120022181
被引量：
年份：
2003
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