Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication
摘要：
Novel acyclic triazole nucleosides with various ethynyl moieties appended on the triazole nucleobase were synthesized efficiently using a convenient one-step Sonogashira reaction in aqueous solution and under microwave irradiation. One of the compounds, 1f, inhibited HCV subgenomic replication with a 50% effective concentration (EC 50) of 22 μg/ml and did not inhibit proliferation of the host cell at a concentration of 50 μg/ml. A preliminary SAR study suggests that the appended phenyl ring as well as the rigid triple bond linker contributes importantly to the anti-HCV activity.
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关键词：
Triazole nucleosides Antiviral activity Anti-HCV Sonogashira reaction Microwave-irradiation promoted reaction
DOI：
10.1016/j.bmcl.2008.04.026
被引量：
年份：
2008
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