Microbial synthesis of chiral intermediates for β-3-receptor agonists

来自 EBSCO

阅读量:

19

作者:

RN PatelA BanerjeeL ChuD BrozozowskiV NanduriLJ Szarka

展开

摘要:

Chiral intermediates were prepared by biocatalytic processes for the chemical synthesis of β-3-receptor agonists. These include: (i) the microbial reduction of 4-benzyloxy-3-methanesulfonylamino-2′-bromoacetophenone 1 to the corresponding ( R )-alcohol 2 by Spingomonas paucimobilis SC 16113. In the biotransformation process, a reaction yield of >85% and an optical purity of 99.5% were obtained for the desired ( R )-alcohol 2 ; (ii) the enzymatic resolution of racemic α-methyl phenylalanine amide, 3 , and α-methyl-4-hydroxy-phenylalanine amide, 5 , by amidase from Mycobacterium neoaurum ATCC 25795 to prepare the corresponding ( S )-amino acids 4 and 6 . Reaction yields of 49.9 and 49 M% (theoretical maximum yield 50 M%) and optical purities of 99 and 94% were obtained for the desired ( S )-amino acids 4 and 6 , respectively; (iii) the asymmetric hydrolysis of methyl-(4-methoxyphenyl)-propanedioic acid, ethyl diester, 7 , to the corresponding ( S )-monoester 8 by pig liver esterase. A reaction yield of 96 M% and an optical purity of 96% were obtained for ( S )-monoester 8 when reactions were carried out in a biphasic system containing 10% ethanol at 10°C.

展开

DOI:

10.1007/s11746-998-0081-0

被引量:

43

年份:

1998

通过文献互助平台发起求助,成功后即可免费获取论文全文。

相似文献

参考文献

引证文献

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

关于我们

百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的学术服务。在这里我们保持学习的态度,不忘初心,砥砺前行。
了解更多>>

友情链接

百度云百度翻译

联系我们

合作与服务

期刊合作 图书馆合作 下载产品手册

©2025 Baidu 百度学术声明 使用百度前必读

引用