Oxidative Stress and Oxidative Damage in Carcinogenesis

来自 Elsevier

喜欢 0

阅读量：

142

作者：

JE Klaunig，LM Kamendulis，BA Hocevar

展开

摘要：

Reactive oxygen species (ROS) are induced through a variety of endogenous and exogenous sources. Overwhelming of and mechanisms in the cell by ROS may result in oxidative stress and oxidative damage to the cell. This resulting oxidative stress can damage critical cellular macromolecules and/or modulate gene expression pathways. by chemical and physical agents involves a multi-step process. This process includes multiple molecular and cellular events to transform a normal cell to a malignant neoplastic cell. Oxidative damage resulting from ROS generation can participate in all stages of the process. An association of ROS generation and has been shown. It appears that oxidative stress may both cause as well as modify the process. Recently association between polymorphisms in oxidative genes and genes (single nucleotide polymorphisms) and susceptibility has been shown.

展开

关键词：

Animals Humans Liver Neoplasms, Experimental Reactive Oxygen Species Transcription Factor AP-1 Oxidation-Reduction Oxidative Stress Polymorphism, Genetic Hypoxia-Inducible Factor 1 NF-E2-Related Factor 2