The relations between structural changes in small airways and pulmonary-function tests.
摘要：
To examine the relation between small-airways abnormalities and specific lung functions, we performed pulmonary-function tests in 36 patients, of whom two were nonsmokers, one to three days before open-lung biopsy for localized pulmonary lesions. The primary lesion in the small airways was a progressive inflammatory reaction leading to fibrosis with connective-tissue deposition in the airway walls. Increase in disease in small airways correlated with deterioration in lung function. Lesions could be reliably detected (P less than 0.05) by tests for closing capacity, the volume at which air and helium flow ere equal (a test of airway caliber and elastic recoil), and the slope of phase III of the single-breath washout curve (which tests evenness of ventilation). These tests showed abnormalities at a time when the pathologic changes were still potentially reversible and when other tests were not appreciably changed.
展开
关键词：
Lung Bronchi Humans Respiratory Function Tests Forced Expiratory Flow Rates Smoking Adult Middle Aged Female Male
DOI：
10.1056/NEJM197806082982303
被引量：
年份：
1978
Taylor & Francis
BMJ
Semantic Scholar
万方医学
dx.doi.org
查看更多
BioMed Central
NCBI
NCBI
Europe PMC
ResearchGate
ProQuest
EBSCO
mysciencework.com
annalspathology.com
pubfacts.com
resmedjournal.com
erj.ersjournals.com
www.socolar.com
tobaccodocuments.org
mendeley.com
jacionline.org
nejm.org
mayoclinicproceedings.org
ajplung.physiology.org
onacademic.com
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
