Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.
摘要：
One of the key features associated with in many tissues is the of apoptotic bodies by macrophages. Removal of apoptotic cells occurs before their lysis, indicating that these cells, during the of , express specific surface changes recognized by macrophages. We have compared the mechanisms by which four different macrophage populations recognize apoptotic cells. macrophages elicited into the peritoneal cavity with either of two different phlogistic agents were able to phagocytose apoptotic cells. This was inhibited by phosphatidylserine (PS), regardless of the species (or ) or type (lymphocyte or neutrophil) of the apoptotic cell. In contrast, the bone marrow macrophage, like the monocyte-derived macrophage, utilized the vitronectin receptor, an alpha v beta 3 integrin, for the removal of apoptotic cells, regardless of their species or type. That macrophages are capable, under some circumstances, of recognizing PS on apoptotic cells was suggested by the observation that PS liposomes inhibited by -treated -1 cells. These results suggest that the mechanism by which apoptotic cells are recognized and phagocytosed by macrophages is determined by the subpopulation of macrophages studied.
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DOI：
10.4049/jimmunol.149.12.4029
被引量：
年份：
1992
BMJ
Semantic Scholar
万方医学
NCBI
Europe PMC
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