摘要：

An organocatalytic asymmetric aza-Henry reaction has been described. Imines, generated in situ from α-amido sulfones 1 , react with nitromethane and cesium hydroxide in the presence of 12 mol% of a chiral quininium salt 2 to give protected nitroamines 3 . Linear and branched alkyl substrates, as well as aryl precursors provide the products in good yields and enantioselectivities. Furthermore, nitroethane can also be used yielding the corresponding products 4 in high syn / anti ratios and similarly good enan­tioselectivities.

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