摘要：

Objective To investigate the positive rate of lactulose hydrogen breath test(LHBT) and the effect of short-term administration of antibiotics in patients with diarrhea-predominant irritable bowel syndrome(IBS-D).Method The LHBTs were detected and the relationship between LHBT and symptom scores of irritable bowel syndrome(IBS) were detected in 89 cases of patients with IBS-D.Antibiotics(tinidazole or sparfloxacin) were administered to 16 patients with LHBT-positive IBS-D for one week,and their effects on the symptom scores of IBS were investigated.Result Among the 89 cases of IBS-D,46 cases(51.7%) were LHBT positive.There were significant difference between the LHBT-positive and-negative IBS-D patients(P0.05) in terms of the degree and the frequency of abdominal pain,as well as abdominal distention.After treatment with antibiotics,ten cases(62.5%) with LHBT-positive turned to LHBT negative and there was a positive correlation between the symptom-improvement rate(Y) and the reduction rate(X) of H2 breath(Y=31.3+0.34X,r=0.61,P=0.03).Conclusion These results indicate that 51.7% of IBS-D patients have small intestinal bacterial overgrowth(SIBO),which contributes to the symptom of abdominal pain and abdominal distension.A short-term antibiotic treatment improves the symptoms in some LHBT-positive IBS-D patients.

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