Imidazole Catalysis. VI.1 The Intramolecular Nucleophilic Catalysis of the Hydrolysis of an Acyl Thiol. The Hydrolysis of n-Propyl γ-(4-Imidazolyl)-thiolbutyrate

来自 ACS

阅读量:

23

作者:

Thomas C. Bruice

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摘要:

In this paper a study is reported in which a group of children with Turner Syndrome (TS) is compared on motor performance tests and real-time kinematic data with a control group. The objective of this study was to identify possible kinematic variables that characterize the movement patterns utilized by this group of children in achieving their optimal performance. The underlying idea is that by comparing test results and movement kinematics one might gain more insight into the movement production of children than by just looking at the test results or by just using clinical movement observation. The children performed a pen and paper task, the flower trail (one of the sub-tests of the Movement ABC) (Henderson and Sugden, 1992), on an XY-tablet. We explored kinematic variables, such as trajectory length, movement time, velocity and pen pressure. It was found that, although girls with TS have a severe motor deficit, they are able to draw a line accurately between two narrow boundaries just as well as the control children (no significant difference in mean number of spatial errors). However, quantitative analysis revealed that girls with TS made a large amount of deviations from the optimal path such that their trajectory length increased with more than 10% per flower trail compared to the control group children. They also made more pen lifts and more changes in velocity. The study showed that children from the two groups may reach the same basic accuracy performance level by using very different strategies. Kinematic registration of fine motor tasks holds promise in gaining more insight into how clinical groups cope with their specific motor problems. Copyright (C) 2003 John Wiley Sons, Ltd.

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DOI:

10.1021/ja01529a048

被引量:

200

年份:

1959

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